Should anorectal manometry be routine before stoma reversal in patients after an intersphincteric resection?

INTRODUCTION: Anorectal manometry (ARM) is sometimes performed before ostomy reversal in patients with an intersphincteric resection (ISR) to predict bowel function. However, no clinical predictive data exist regarding its utility. METHODS: The single-centre, retrospective data of ISR patients who had an ARM prior to ostomy reversal, and bowel functional assessment with the low anterior resection syndrome (LARS) and Wexner incontinence scores at least 6 months after reversal, were considered. Correlation statistics were performed with each of the manometric parameters and functional outcome categories. RESULTS: Eighty-nine patients were included. The median basal and squeeze pressures were 41 and 100 mmHg, respectively. Any LARS (score ≥20) and major incontinence (score ≥11) was observed in 51.7% and 16.9%, respectively. None of the manometric parameters (median basal or maximum squeeze pressure, anal canal length, volume at urge and the ability to expel) correlated with LARS or incontinence. CONCLUSIONS: Anorectal manometry (ARM) before ostomy reversal to predict bowel function at 6 months or beyond was not helpful in patients with an ISR and diverting stoma. No manometric parameter correlated with the LARS or Wexner incontinence scores.

Functional outcomes after robotic or laparoscopic intersphincteric resection - An inverse probability weighting analysis.

BACKGROUND: Functional outcomes after robotic and laparoscopic Intersphincteric resections (ISR) have not been studied adequately. We aimed to compare the bowel functions after robotic or laparoscopic ISR. METHODS: Single-center, cross-sectional study of minimally invasive ISR. Functional outcomes were assessed on the low anterior resection syndrome (LARS), Wexner incontinence scale, and the Kirwan grading. Baseline characteristics (age, sex, body mass index, T stage, tumour height, preoperative radiation, and anastomotic configuration) in the groups were balanced using inverse probability of treatment weighting (IPTW). RESULTS: Functional outcomes were assessed for 132 patients, 85 laparoscopic and 47 robotic ISR were performed. After IPTW, baseline characteristics were well balanced (mean deviation <0.1). In the weighted cohorts of laparoscopic and robotic ISR, major LARS was observed in 18.1% and 18.5% (p - 0.182) and major incontinence on the Wexner scale in 18.4% and 22.8% (p - 0.443), respectively. The Kirwan grades of incontinence were also similar between the groups (p - 0.794). CONCLUSION: No differences in bowel functions on the LARS and incontinence scales between laparoscopic and robotic ISR were found in the present study.

Bowel Functional Outcomes After Long-Course or Short-Course Radiation for Advanced Rectal Cancers: A Propensity-Matched Analysis.

BACKGROUND: Despite short-course radiation and chemotherapy gaining popularity because of similar or better oncological outcomes, functional outcomes relative to long-course radiation have not been evaluated. OBJECTIVE: To compare bowel function outcomes after long-course or short-course radiation and delayed operation for advanced rectal cancers. DESIGN: Propensity-matched analysis. SETTINGS: This study was conducted at a single tertiary cancer center. Patients were operated on between 2014 and 2020. PATIENTS: The study included patients with locally advanced, nonmetastatic, mid, and low rectal cancers who underwent low anterior resection with stapled anastomosis and diverting ostomy. Extended or beyond total mesorectal excisions and lateral node dissections were excluded. INTERVENTIONS: Long-course radiation delivered as a radiation dose of 50 Gy in 25 fractions or short-course radiation (5 Gy in 5 fractions) and delayed surgery after 4 to 6 weeks with or without chemotherapy. MAIN OUTCOME MEASURES: One-time assessment of low anterior resections syndrome and Wexner incontinence scores at least 6 months after stoma reversal. RESULTS: After matching 124 patients in the 1:2 ratio between short- and long-course radiations, 93 patients were included for analysis. Any low anterior resection syndrome was found in 90.3% of short-course patients compared to 54.8% after long-course radiation (p < 0.001). Major incontinence was detected in 6.5% after short-course radiation as opposed to 8.1% of patients after long-course radiation (p = 0.781). On multivariate logistic regression, short-course radiation predicted the development of any low anterior resection syndrome with an OR of 4.4. LIMITATIONS: Selection and misclassification biases from retrospective recruitment. CONCLUSIONS: For patients with locally advanced, nonmetastatic, mid, and low rectal cancers who underwent preoperative radiation followed by stapled low anterior resection, short-course radiation had higher probability of developing low anterior resection syndrome than long-course radiation. See Video Abstract at http://links.lww.com/DCR/C37. RESULTADOS DE LA FUNCIN INTESTINAL DESPUS DE LA RADIACIN DE CICLO LARGO O CORTO EN CNCER DE RECTO AVANZADO UN ANLISIS EMPAREJADO DE PROPENSIN: ANTECEDENTES:A pesar de que la radiación de corta duración y la quimioterapia están ganando popularidad debido a resultados oncológicos similares o mejores, los resultados funcionales en relación con la radiación de larga duración no han sido evaluado.OBJETIVO:Comparar resultados de la función intestinal después de la radiación de ciclo largo o corto y cirugía diferida para los en cáncer de recto avanzado.DISEÑO:Análisis emparejado de propensión.ENTORNO CLINICO:Centro único de cáncer terciario. Pacientes operados entre 2014 y 2020.PACIENTES:Cánceres de recto medio y bajo localmente avanzados, no metastásicos, que se sometieron a resección anterior baja con anastomosis grapada y ostomía de derivación. Se excluyeron las escisiones total de mesorecto extendidas o más allá del plano y las disecciones de los ganglios laterales.INTERVENCIONES:Radiación de ciclo largo administrada como 50 Gy en 25 fracciones o radiación de ciclo corto (5 Gy en 5 fracciones) y cirugía diferida después de 4 a 6 semanas con o sin quimioterapia.PRINCIPALES MEDIDAS DE RESULTADO:Evaluación única del síndrome de reseccion anterior baja y escala de Wexner de incontinencia al menos seis meses después de la restitución del tránsito intestinal.RESULTADOS:Después de emparejar 124 pacientes en la proporción 1:2 entre radiación de ciclo corto y largo, se incluyeron 93 pacientes para el análisis. Se encontró cualquier síndrome de resección anterior baja en el 90,3% de los pacientes de ciclo corto en comparación con el 54,8% después de la radiación de ciclo largo (p < 0,001). Se detectó incontinencia grave en el 6,5% después de un tratamiento de corta duración frente al 8,1% de los pacientes que recibieron un tratamiento de radiación de larga duración (p = 0,781). En la regresión logística multivariable, la radiación de corta duración predijo el desarrollo de cualquier síndrome de resección anterior baja con una probabilidad de 4,4.LIMITACIONES:Sesgos de selección y clasificación errónea de reclutamiento retrospectivo.CONCLUSIONES:Para los cánceres de recto medio e inferior localmente avanzados, no metastásicos, que se sometieron a radiación preoperatoria seguida de resección anterior baja con grapas, curso corto tuvo una mayor probabilidad de desarrollar síndrome de resección anterior baja en comparación con radiación de curso largo. Consulte Video Resumen en http://links.lww.com/DCR/C37. (Traducción- Dr. Francisco M. Abarca-Rendon).

Incidence and Treatment Outcomes of Rectovaginal Fistula After Rectal Cancer Resection.

OBJECTIVES: Rectovaginal fistulas (RVFs) are an uncommon and disturbing complication with limited success in treatment. This study was aimed at determining the incidence of RVFs after rectal resections in the era of neoadjuvant radiation therapy and the outcomes of their treatment. METHODS: This was a retrospective study of female patients who underwent sphincter-preserving total mesorectal excision for rectal cancer and developed RVF. RESULTS: Four hundred eighty-eight patients underwent rectal resections between January 2013 and December 2019, and 9 developed RVF (1.8%). Average time to presentation was 280 days (range, 6-540 days). The median time to onset for those presenting prior to stoma reversal was 90 days, whereas the duration between stoma reversal and RVF detection in those presenting after stoma closures was 115 days. Success rates of fecal diversion and local procedures for treatment of RVF were 20% (2/10 procedures) and 40% (2/5 procedures), respectively. Redo coloanal anastomosis was performed for 2 patients with successful outcome. An average of 2.1 procedures were performed per patient (19/9) with a per-procedure success rate of 31.6% (6/19 procedures) and a per-patient success rate of 66.7% (6/9). At median follow-up of 64 months, 50% (3/6) of patients with a healed fistula were free of stoma, and all of them were continent. Four patients were sexually active. CONCLUSIONS: The incidence of RVF after rectal resection is low, but treatment outcomes are disappointing. Diversions and local repairs had high failure rates in our patients where the majority received preoperative radiation therapy. After successful healing, sexual function and continence are acceptable.

Comparative study of functional outcomes between ultra-low anterior resection and inter-sphincteric resection: a propensity matched analysis.

BACKGROUND: Comparative bowel functional outcomes between ultralow anterior resections (ULAR) and inter-sphincteric resection (ISR) for similar tumour and patient characteristics is not known. METHODS: Single centre study of low rectal caners (<5cm from anal verge) with 1:1 propensity matching of age, sex, body mass index, prior radiation, and surgical approach (open vs. minimally invasive) was performed for the ULAR and ISR groups. Primary outcome measure was Wexner Incontinence scores and Low Anterior Resection Syndrome (LARS) score at a single time point after stoma reversal. RESULTS: Seventy-two matched patients were included. Median Wexner scores were five and eight for the ULAR and ISR cohorts (p = 0.006). Major incontinence (Wexner >11) was found in 5.6% versus 33% after ULAR and ISR, respectively. Major LARS (score > 29) was demonstrated in 11% versus 25% in ULAR versus ISR (p = 0.293). Majority in both groups has no LARS (score < 20), that is, 72.2% versus 63.9% in ULAR against ISR. Besides these, stool fragmentation (p < 0.001), nocturnal defecation (p < 0.001) and use of anti-diarrhoeal medications (p = 0.023) were significantly more after ISR. CONCLUSIONS: Bowel continence was relatively inferior after ISR as compared to an ULAR for low rectal cancers in matched cohorts. Major LARS in ISR was twice as prevalent without statistical differences.

Ileal cavernous haemangioma in an adult presenting as a rare cause of small bowel obstruction.

Haemangiomas of the small bowel are a very rare entity and rarely considered as an aetiology for an intestinal obstruction. Contrast-enhanced CT is the investigation of choice but the lesion can be confused with malignancy or rarely a neuroendocrine tumour. Commonly it presents as abdominal pain with anaemia and/or melaena. With patients presenting without obstruction or acute gastrointestinal bleed, capsule endoscopy has shown to be a useful diagnostic tool.We present here our experience of managing a case of a patient with ileal haemangioma who presented with a subacute small bowel obstruction and underwent a laparoscopic-assisted ileal segmental resection with side-to-side anastomosis. The lesion was a cavernous haemangioma on histopathological analysis.

Perianal Paget's Disease-a Case Report and a Review of Current Diagnosis and Management.

Paget's disease is an intraepithelial adenocarcinoma arising from the apocrine gland component of the skin. Paget's disease is most common in the breast but extra mammary disease is also seen. Perianal Paget's disease is a rare form of extramammary disease with few cases reported in literature. It can be primary-arising from the skin or secondary-cutaneous metastases of anorectal or genitourinary malignancy. We hereby wish to report a case of perianal Paget's disease that presented as an eczematous lesion and was diagnosed incidentally on biopsy. After appropriate staging, the patient underwent wide local excision till negative margins were obtained. The resultant tissue defect was successfully covered by split-thickness skin grafting.

Large gastric trichobezoar in a normal healthy woman: case report and review of pertinent literature.

This report presents a unique case of a gastric trichobezoar in a relatively healthy, young female with no history of psychological or psychiatric disorders. Furthermore, unlike previously reported cases, this patient had no history of gastric surgery. The mode of presentation and the difficulties in diagnosis are discussed. The different modalities of treatment, both surgical and nonsurgical, are evaluated and discussed. The diagnosis of a trichobezoar in a healthy patient requires a high index of suspicion, as it can present with nonspecific symptomatology. It should be included in the differential diagnosis of nonspecific abdominal pain.